Saturday, October 30, 2010


Learn from yesterday

Live for today

Hope for tomorrow

-Albert Einstein

Wednesday, October 27, 2010


Viagra May be Heart Helper in DMD

The erectile-dysfunction drug sildenafil (Viagra) conferred heart protection and reversal of heart-muscle damage in Duchenne muscular dystrophy research mice.

Viagra, informally referred to as "the little blue pill," has been shown to benefit the hearts of mice with a disease resembling Duchenne muscular dystrophy.

* Results from a new study show that the erectile-dysfunction drug sildenafil imparts cardioprotective effects in mice with both an early- and late-stage DMD-like disease.
* Sildenafil belongs to a class of drugs called phosphodiesterase 5 (PDE5) inhibitors, which relax the smooth muscles lining blood vessels, increasing blood flow to muscles and the heart.
* The new findings, along with the results from several previous studies, suggest that PDE5 inhibitors may be effective treatments for DMD- and BMD-associated cardiomyopathy.
* PDE5 inhibitors already have been FDA-approved for treatment of erectile dysfunction and high blood pressure in humans; this may speed the testing and approval process for their use as a treatment in muscular dystrophy.

The results from these studies suggest that PDE5 inhibitors like sildenafil and tadalafil may be effective treatments for DMD- and BMD-associated cardiomyopathy, both in the early and late stages of the diseases.

More testing will be needed, however, to determine the precise way in which these drugs impart cardioprotective effects.

Although PDE5 inhibitors ultimately will not cure DMD, current studies suggest the possibility that they may be used in combination with other current or future therapies, say the study authors, noting that "targeting skeletal muscle repair without cardiac treatment exacerbates damage to the heart, emphasizing the importance for a cardiac-specific treatment."

Because PDE5 inhibitors already have been FDA-approved for use in humans, the testing and approval process for their use as a treatment in muscular dystrophy potentially may be shorter than for an experimental treatment.

Thursday, October 14, 2010

{which movie love story is my life?}

A fortunate accident

Actually, I have never seen this movie so I have no idea if this is true...

Friday, October 8, 2010

{which city do I belong in?}

Denver, Colorado

This seemingly boring cow town is anything but. It features the best mountains in America, and its people lead healthy, active lifestyles.

{which high school stereotype am i?}

I am an Ugly Duckling. I am sweet and shy. I am very self-conscious, avoiding attention, trying not to be noticed. I work at pleasing others, even if I am hurt in the process. I do my best to look nice and keep up with the latest styles, but I can never get it right. Others pick on me and others feel sorry for me. I may not get everything I want, but I know who I am.

Wednesday, October 6, 2010

{which harry potter character am i?}

Narcissa Malfoy
Strong, determined, willful. People may view me as a pushover, but I most certainly am not. I like to fit in with the situation that best suits my survival. I never really go against anyone, and am with very few. Those I do let in are very dear to me and I would do anything to protect them, even if that meant climbing out of my comfort zone. I sometimes make the wrong decisions because I wish to be with those I care about, but in my minds eye, if if helps them it is the right thing.